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Bone Cancer: Types, Causes, Symptoms, and More

Bone cancer is a rare and often aggressive form of cancer that originates in the bones. It can manifest as either primary bone cancer, where the cancerous cells develop directly in the bone tissue, or secondary bone cancer, which occurs when cancer from another part of the body spreads to the bones. Common symptoms include persistent bone pain, fractures, and swelling. Treatment options may include surgery, chemotherapy, radiation therapy, or a combination of these approaches, depending on the type, stage, and location of the cancer. Early detection and prompt medical intervention are crucial for improving the prognosis and quality of life for individuals with bone cancer.

Types of Bone Cancer


Osteosarcoma is the most common type of primary bone cancer, often occurring in the long bones, such as the arms and legs. It is most frequently diagnosed in adolescents and young adults.


Chondrosarcoma develops in the cartilage cells of the bone and typically affects the pelvis, hip, and shoulder bones. It primarily affects adults, particularly those over the age of 40.

Ewing’s Sarcoma

Ewing’s sarcoma mainly occurs in the long bones of the arms and legs, as well as the pelvis, ribs, and spine. It is most commonly found in adolescents and young adults.

Giant Cell Tumor of Bone

This type of bone tumor is usually benign (non-cancerous), but it can be locally aggressive. It often occurs in the bones around the joints, such as the knee or wrist.


Chordoma is a rare cancer that develops in the bones of the skull base and the spine. It typically affects adults.

Fibrosarcoma of Bone

Fibrosarcoma is a rare malignant tumor that can develop in the bones, usually in the arms or legs.

Undifferentiated Pleomorphic Sarcoma (UPS) of Bone

UPS is a rare and aggressive type of bone cancer that can develop in various bones of the body.

In addition to primary bone cancer, there is also secondary bone cancer, which occurs when cancer from another part of the body (such as the breast, lung, or prostate) spreads to the bones. This type of cancer is also known as metastatic bone cancer.

What are the Symptoms of Bone Cancer

  • Bone Pain: Persistent and increasing bone pain is a common symptom of bone cancer. The pain may initially be mild and intermittent but often becomes more severe and constant over time. It may worsen at night or with physical activity.
  • Swelling or Lump: Swelling or a lump may develop near the affected bone. This swelling is often painless, but it can be associated with tenderness.
  • Fractures: Bone weakened by cancer may be more prone to fractures (broken bones). A fracture can occur even with minor trauma or stress to the bone.
  • Limited Range of Motion: Depending on the location of the tumor, bone cancer can limit the range of motion in nearby joints. This can lead to stiffness or difficulty in moving the affected limb.
  • Fatigue: General fatigue and weakness can occur, especially as the cancer progresses. This is often due to the body’s response to the cancer and the physical toll it takes.
  • Unintended Weight Loss: Some people with bone cancer may experience unintended weight loss. This can be due to the cancer affecting metabolism or appetite.
  • Fever: In some cases, bone cancer can lead to fever, although this is less common.

It’s important to note that these symptoms can be caused by various other conditions, and having one or more of these symptoms does not necessarily mean you have bone cancer. If you experience persistent or worsening bone pain or any of these symptoms, it’s essential to consult a healthcare professional for a thorough evaluation. Early diagnosis and treatment can significantly improve the prognosis for bone cancer. Diagnostic tests such as X-rays, MRI scans, CT scans, and bone biopsies may be necessary to confirm a diagnosis of bone cancer.

What Causes of Bone Cancer

Genetic Factors

Some rare inherited genetic mutations can increase the risk of developing bone cancer. Conditions like Li-Fraumeni syndrome and hereditary retinoblastoma have been associated with a higher risk of bone cancer.

Radiation Exposure

Exposure to high doses of ionizing radiation, such as radiation therapy for other cancers, can increase the risk of developing bone cancer, although this is relatively rare.

Paget’s Disease

Paget’s disease of the bone is a rare condition that affects bone growth and repair. In some cases, it can increase the risk of bone cancer developing in affected bones.

Preexisting Conditions

Certain non-cancerous bone conditions, such as osteochondroma and fibrous dysplasia, may increase the risk of bone cancer.

Who is at risk for bone cancer?

Primary bone cancer risk factors:

Age: Primary bone cancers, such as osteosarcoma and Ewing sarcoma, are more common in children and young adults, although they can occur at any age.

Genetic factors: Some genetic syndromes and mutations can increase the risk of developing bone cancer. For example, individuals with hereditary retinoblastoma or Li-Fraumeni syndrome have an increased risk.

Radiation exposure: Previous exposure to high levels of ionizing radiation, such as in the treatment of other cancers or due to environmental factors, may increase the risk of bone cancer.

Secondary bone cancer risk factors:

Secondary bone cancer occurs when cancer from another part of the body (usually breast, lung, or prostate cancer) spreads to the bones (metastasis). In such cases, the risk factors are typically related to the primary cancer:

Cancer type: Certain types of cancer are more likely to spread to the bones. For example, breast, lung, and prostate cancers are commonly associated with bone metastasis.

Stage of the primary cancer: Advanced stages of cancer are more likely to metastasize to the bones.

Treatment history: Some cancer treatments, such as radiation therapy and certain types of chemotherapy, can increase the risk of developing secondary bone cancer.

It’s important to note that the majority of bone cancers are not linked to specific risk factors, and many people diagnosed with bone cancer do not have any known risk factors. Additionally, bone pain or other symptoms may be indicative of various medical conditions, so it’s important to consult a healthcare professional for an accurate diagnosis if you have concerns about bone health or cancer risk. Early detection and treatment can improve the outlook for individuals with bone cancer.

Treatment of Bone Cancer


Surgery is often the primary treatment for bone cancer. The goal of surgery is to remove the cancerous tumor along with a margin of healthy tissue to ensure that all cancer cells are removed. In some cases, amputation may be necessary if the tumor is large or in a location where complete removal is challenging. However, limb-sparing surgery is preferred whenever possible to preserve function.


Chemotherapy involves the use of drugs to kill cancer cells or prevent their growth and spread. It is often used in combination with surgery to shrink tumors before surgery or to treat cancer that has spread to other parts of the body (metastatic bone cancer).

Radiation therapy

Radiation therapy uses high-energy X-rays or other types of radiation to target and destroy cancer cells. It may be used before or after surgery, depending on the specific situation.

Targeted therapy

Targeted therapies are drugs that specifically target the abnormal molecules or pathways involved in cancer growth. They are sometimes used in combination with other treatments, especially for more advanced or aggressive forms of bone cancer.


Immunotherapy is a relatively new approach to cancer treatment that stimulates the body’s immune system to recognize and attack cancer cells. It is being studied in clinical trials for some types of bone cancer.

Supportive care

Managing pain and other symptoms is an essential part of bone cancer treatment. Supportive care may include pain medications, physical therapy, and other measures to improve the patient’s quality of life.

The specific treatment plan for an individual with bone cancer will be determined by a team of healthcare professionals, including orthopedic surgeons, medical oncologists, radiation oncologists, and other specialists. It’s important for patients to discuss their treatment options, potential side effects, and expected outcomes with their healthcare team to make informed decisions about their care.

In addition to medical treatment, emotional and psychological support is crucial for patients with bone cancer. Support groups, counseling, and a strong support system can help patients and their families cope with the challenges of bone cancer treatment.

Also Read : Cancer: Definition Types, Causes, Prevention, and Treatment

Ashish Matoliya
Ashish Matoliya
Ashish brings a unique blend of expertise, empathy, and practical guidance to his writing. His articles are not just informative but also designed to inspire and motivate. Whether you're looking for workout tips, strategies for managing mental health, or seeking to improve your overall well-being, Ashish's content is your roadmap to a healthier and happier life.


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