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Spleen Cancer: Causes, Diagnosis, Symptoms and Treatment

Spleen cancer, also known as splenic cancer, is a rare and often aggressive form of cancer that originates in the spleen, a vital organ in the immune and circulatory systems. The spleen plays a crucial role in filtering the blood, removing damaged blood cells, and storing platelets. When cancer cells develop in the spleen, they can disrupt its normal functions and potentially spread to other parts of the body. Spleen cancer is a relatively uncommon diagnosis, and its symptoms may vary, including pain or fullness in the upper left abdomen, unexplained weight loss, and fatigue. Treatment options for spleen cancer typically involve surgery to remove the affected spleen, and in some cases, may include chemotherapy or radiation therapy. Early detection and prompt medical attention are essential for improving the prognosis of individuals with spleen cancer.

spleen cancer symptoms

Spleen cancer, also known as splenic cancer or splenic neoplasm, is a rare type of cancer that originates in the spleen, which is an organ located in the upper left side of the abdomen. Symptoms of spleen cancer can vary, and in some cases, the cancer may be asymptomatic (showing no symptoms) in its early stages. When spleen cancer symptoms do occur, they can include:

  • Pain or discomfort: Pain in the upper left abdomen (left hypochondrium) is a common symptom. This pain may be dull, aching, or sharp. It can also radiate to the left shoulder or back.
  • Feeling of fullness or pressure: Some individuals with spleen cancer may experience a sensation of fullness or pressure in the abdomen, particularly after eating, even when they haven’t consumed a large meal.
  • Abdominal swelling: Swelling of the abdomen, known as abdominal distension, may occur in some cases. This can make the abdomen appear larger or feel bloated.
  • Unexplained weight loss: Rapid and unexplained weight loss can be a sign of various cancers, including spleen cancer. This weight loss can be significant and not related to changes in diet or exercise.
  • Fatigue: General fatigue and weakness are common symptoms of many types of cancer, including spleen cancer. This fatigue may be severe and not alleviated by rest.
  • Anemia: Spleen cancer can lead to a decrease in the number of red blood cells, resulting in anemia. Anemia can cause symptoms like pale skin, weakness, and shortness of breath.
  • Fever and infection: Spleen cancer can weaken the immune system and make individuals more susceptible to infections. Persistent fever or recurrent infections may be a symptom.
  • Easy bruising or bleeding: A decrease in the number of platelets (thrombocytopenia) due to spleen cancer can lead to easy bruising and prolonged bleeding from minor injuries.

Causes of Spleen Cancer

Spleen cancer, also known as splenic cancer or splenic neoplasm, is a rare form of cancer that originates in the spleen. The exact causes of spleen cancer are not well understood, but several factors and risk factors have been associated with an increased likelihood of developing this condition. These factors may include:

Primary Spleen Cancers

There are two main types of primary spleen cancers: splenic lymphomas and angiosarcomas. These cancers are believed to develop from cells within the spleen itself. The causes for their development are largely unknown.

Metastatic Cancer

Spleen metastases, where cancer from other parts of the body spreads to the spleen, are more common than primary spleen cancer. In this case, the underlying cause is the cancer originating in another organ or tissue.

Genetic Factors

Some genetic syndromes, like Li-Fraumeni syndrome, are associated with an increased risk of developing spleen cancer.

Radiation Exposure

Previous exposure to high levels of ionizing radiation, such as radiation therapy for other cancers, may increase the risk of spleen cancer.

Chemical Exposures

Exposure to certain chemicals and toxins, such as vinyl chloride and arsenic, has been linked to an increased risk of splenic angiosarcoma.

Chronic Infections

Certain chronic infections, like Epstein-Barr virus (EBV), have been associated with an increased risk of lymphomas, which can potentially affect the spleen.


People with compromised immune systems, such as those who have undergone organ transplantation and are on immunosuppressive medications, may have a higher risk of developing cancer, including spleen cancer.

Age and Gender

Spleen cancer tends to occur more frequently in older adults, with the risk increasing with age. It is slightly more common in men than in women.

Other Medical Conditions

Certain medical conditions, such as hematologic disorders or liver disease, can be associated with an increased risk of developing spleen cancer.

How is it diagnosed?

Diagnosing spleen cancer typically involves a combination of medical history assessment, physical examination, and various diagnostic tests and procedures. Here’s an overview of the steps involved in the diagnosis of spleen cancer:

Medical History and Physical Examination

  • Your healthcare provider will begin by taking a detailed medical history, including any symptoms you may be experiencing and any risk factors you might have.
  • They will perform a physical examination, including palpating (feeling) your abdomen to check for an enlarged spleen or any other abnormalities.

Blood Tests

  • Blood tests, including a complete blood count (CBC) and blood chemistry tests, may be conducted to assess the overall health of your blood and to detect any abnormalities, such as low blood cell counts.

Imaging Studies

Various imaging tests are used to visualize the spleen and nearby structures. Common imaging studies include:

  • Ultrasound: This non-invasive test uses sound waves to create images of the spleen and surrounding areas.
  • Computed Tomography (CT) Scan: CT scans provide detailed cross-sectional images of the abdomen, which can help identify abnormalities in the spleen.
  • Magnetic Resonance Imaging (MRI): MRI scans use strong magnetic fields and radio waves to create detailed images of the spleen and nearby organs.
  • Positron Emission Tomography (PET) Scan: PET scans may be used to determine the extent of cancer or assess whether it has spread to other parts of the body.


If imaging studies suggest the presence of spleen cancer, a biopsy is typically required to confirm the diagnosis. A biopsy involves taking a small sample of tissue from the spleen for examination under a microscope. There are several methods for obtaining a spleen biopsy, including:

  • Fine-needle aspiration (FNA): A thin, hollow needle is used to extract a sample of tissue from the spleen.
  • Core needle biopsy: A larger, thicker needle is used to obtain a larger tissue sample.
  • Open surgical biopsy: In some cases, an open surgical procedure may be necessary to obtain a biopsy if FNA or core biopsy are not feasible.

Histopathology and Laboratory Analysis

  • The tissue sample obtained through the biopsy is sent to a pathology laboratory, where it is examined by a pathologist. They will determine whether cancer cells are present, and if so, what type of cancer it is.

Treatment of Spleen Cancer

Spleen cancer is a rare form of cancer, and treatment options may vary depending on the type and stage of cancer, as well as the individual’s overall health. The two primary types of spleen cancer are primary splenic malignancies and secondary or metastatic cancers that have spread to the spleen from other parts of the body.


In cases of primary splenic malignancies, surgical removal of the spleen (splenectomy) is often the preferred treatment. This is typically done if the cancer is confined to the spleen and has not spread to other parts of the body. In some cases, partial splenectomy (removing only a portion of the spleen) may be an option to preserve some of the spleen’s function.


Chemotherapy may be used before or after surgery to treat certain types of spleen cancer or in cases where surgical removal is not possible. It can also be used for metastatic or advanced cases to help control the spread of the cancer and alleviate symptoms.

Radiation therapy

Radiation therapy involves the use of high-energy rays to target and destroy cancer cells. It may be used alone or in combination with other treatments, particularly for specific types of spleen cancers.

Targeted therapy

Some advanced cancers may respond to targeted therapies, which are drugs designed to target specific molecular abnormalities in cancer cells. These therapies are used to block the growth and spread of cancer.


Immunotherapy is an evolving field, and in some cases, it may be considered as part of treatment. Immunotherapies can help the immune system recognize and attack cancer cells.

Supportive care

Management of symptoms and side effects is an essential part of spleen cancer treatment. This may include pain management, blood transfusions, or addressing other complications.

The Bottom Line

Spleen cancer is a rare condition, and treatment options depend on the type and stage of the cancer. Consult with a healthcare specialist for a personalized treatment plan and explore the latest advancements in cancer research for hope and progress in the fight against this disease.

Ashish Matoliya
Ashish Matoliya
Ashish brings a unique blend of expertise, empathy, and practical guidance to his writing. His articles are not just informative but also designed to inspire and motivate. Whether you're looking for workout tips, strategies for managing mental health, or seeking to improve your overall well-being, Ashish's content is your roadmap to a healthier and happier life.


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